FORMULATION AND EVALUATION OF TINIDAZOLE ENTERIC COATED TABLETS FOR COLON TARGETING DRUG DELIVERY SYSTEM

Fatehalrahman F. Magbool; Elamin Ibrahim Elnima; Shayoub M. E.

doi:10.22270/ujpr.v10i4.1391

Fatehalrahman F. Magbool Red Sea University, Sudan.
Elamin Ibrahim Elnima Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan.
Shayoub M. E. Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan.

10.22270/ujpr.v10i4.1391

Keywords:

Compatibility testing, colon-targeted drug, enteric coated tablets, gastro intestinal tract, tinidazole

Abstract

Aim and Objective: Colon-specific delivery systems have garnered significant attention for their capacity to localize therapy within the large intestine, thereby enhancing treatment efficacy for colonic disorders and reducing systemic toxicity.

Methods: Core tablets containing tinidazole were prepared using a variety of polymers in distinct ratios, followed by application of an enteric coating. Pre-compression evaluation included assessment of powder flow characteristics and compatibility checks between the drug and excipients via FT-IR spectroscopy, with all batches demonstrating no evidence of interaction. Post-compression, tablets were tested for weight uniformity, mechanical strength, friability, and content uniformity, alongside in vitro dissolution studies under conditions simulating gastrointestinal transit.

Results: All formulations exhibited acceptable chemical and physical properties, with assay values ranging from 98.44 % to 99.89 %, indicating consistent drug loading across batches F1 through F5. The F5 batch emerged as the optimal candidate, sustaining tinidazole release for six hours and achieving a cumulative release of 98.32 %. Stability testing of F5 at 45 °C and 75 % relative humidity over three months revealed no significant changes in performance or integrity. Consequently, formulation F5 is proposed as a robust platform for targeted colonic delivery of tinidazole.

Conclusion: The investigation achieved the formulation of enteric-coated tinidazole tablets optimized for oral delivery and targeted release in the distal gastrointestinal tract.

Peer Review History:

Received 9 June 2025; Reviewed 14 July 2025; Accepted 23 August; Available online 15 September 2025

Academic Editor: Dr. DANIYAN Oluwatoyin Michael, Obafemi Awolowo University, ILE-IFE, Nigeria, toyinpharm@gmail.com

Reviewers:

Dr. Ali Awad Allah Ali Moh. Saeed, National University, Sudan, alimhsd@gmail.com

Ali Jaber, Laboratory for Research and Development of Medicines and Natural Products, RDMPN, Faculty of Pharmacy, Lebanese University, Beirut, Lebanon, ali.jaber.2@ul.edu.lb