_1784111031 20260715102351000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 07 15 2026 Emmanuel Ifeanyi Obeagu Idi Musimwa Myeloid cancers, such as acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and myeloproliferative neoplasms (MPNs), develop from the clonal alteration of hematopoietic stem and progenitor cells. Apart from genetic mutations, epigenetic dysregulation has become a key factor in disease onset, advancement, and resistance to treatment. Anomalies in DNA methylation, histone changes, and chromatin rearrangement interfere with normal blood cell differentiation, promote clonal growth, and create diverse malignant cell populations. Alterations in essential epigenetic regulators like DNMT3A, TET2, IDH1/2, ASXL1, and EZH2-collaborate with oncogenic alterations to facilitate leukemogenesis and resistance to treatment. These epigenetic changes act as prognostic indicators and offer targetable weaknesses, such as DNA methyltransferase inhibitors, histone deacetylase inhibitors, and therapies aimed at mutant IDH or EZH2. This review compiles existing information on the epigenetic features of myeloid tumors, emphasizing its importance in disease advancement and treatment strategies.                   Peer Review History: Received 3 April 2026;   Reviewed 12 May 2026; Accepted  7 June; Available online 15 July 2026 Academic Editor: Dr. Ahmad Najib, Universitas Muslim Indonesia,  Indonesia, ahmad.najib@umi.ac.id Reviewers: Dr. Fátima Morales Marín, University of Murcia, Spain, fatima.morales@um.es Dr. Francis Adou Yapo, Felix Houphouet Boigny, University of Abidjan, Ivory Coast, fyapo@yahoo.fr 07 15 2026 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v11i3.1579 https://ujpronline.com/index.php/journal/article/view/1579 https://ujpronline.com/index.php/journal/article/download/1579/2187 https://ujpronline.com/index.php/journal/article/download/1579/2187 https://ujpronline.com/index.php/journal/article/download/1579/2188 https://ujpronline.com/index.php/journal/article/download/1579/2214