_1784110803 20260715102003000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 07 15 2026 Nuha Abdul Aziz Al-Yousfi Ibrahim Mohammed Amed Nahshal Sami Mohammed Abdo Hassan Emad Hassan Al-Shamahi Khaled Abdul Karim Al-Moyed Nawal Mohammed Al-Hababi Sami Sultan Ahmed Abdu Hassan Abdulwahab Al-Shamahy Background and aims: Among the most prevalent bacterial infections are UTIs, especially in cancer patients with compromised immune systems. The patients' vulnerability to infection and antibiotic resistance frequently worsen these infections, making empirical treatment challenging. In order to improve the empirical treatment of UTIs with antibiotics, the study is carried out to determine the antibiotic resistance pattern of UTI bacteria among cancer patients at the National Oncology Centre. Methods: An ongoing prospective follow-up research was conducted at the National Oncology Centre in the city of Sana'a, Yemen, from October to December 2025, involving 290 cancer patients (157 females and 133 males) aged 2 to 76, with a mean age of 32.7 years. Data on clinical, demographic, and factors influencing urinary tract infections (UTIs) were collected, followed by midstream urine samples to culture potential UTI pathogens on blood and MacConkey agar. Results: The largest group of cancer patients is aged 26-35 years (24.1%), with a majority female representation (54.1%). Breast cancer is the most prevalent, constituting 26.9% of cases, followed by Hodgkin's lymphoma and other types at 10.7% each, with leukemia and head and neck cancer at 10%. Pathogenic strains like Escherichia coli and S. saprophyticus were the dominant causes of UTI. Antibiotic susceptibility, revealing E. coli shows 100% resistance to cefixime, while imipenem and meropenem maintain high sensitivity at 68.4%. S. saprophyticus has high sensitivity to vancomycin (95.7%) and linezolid but significant resistance to cefixime (78.3%) and augmentin (56.5%). Conclusions: The results highlight two primary health concerns: a high prevalence of cancer among young adults (particularly females with breast cancer) and a widespread crisis of beta-lactam antibiotic resistance in UTI-causing bacteria. Overall, significant resistance to beta-lactam antibiotics was noted among isolates.                             Peer Review History: Received 3 April 2026;   Reviewed 9 May 2026; Accepted  6 June; Available online 15 July 2026 Academic Editor: Dr. Ahmad Najib, Universitas Muslim Indonesia,  Indonesia, ahmad.najib@umi.ac.id Reviewers: Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, ahsndkyc@gmail.com Prof. Gorkem Dulger, Duzce University, Turkey, gorkemdulger@yandex.com 07 15 2026 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v11i3.1573 https://ujpronline.com/index.php/journal/article/view/1573 https://ujpronline.com/index.php/journal/article/download/1573/2177 https://ujpronline.com/index.php/journal/article/download/1573/2177 https://ujpronline.com/index.php/journal/article/download/1573/2178 https://ujpronline.com/index.php/journal/article/download/1573/2206