_1784110742 20260715101902000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 07 15 2026 Suhail Abdullah Sallam Noor Aldeen Al-Jaber Somaia Ganah Nawal Mohammed Al-Hababi Emad Hassan Al-Shamahi Esmail Mohammed Saad Al-Dabis Hassan Abdulwahab Al-Shamahy Background and objective: High rates of morbidity and mortality are associated with heart failure, and these rates rise as the population ages. The purpose of the study was to compare left ventricular ejection fraction (LVEF) using Simpson's technique and systolic myocardial velocity (Sm) using tissue Doppler imaging (TDI) in Yemeni patients with heart failure (HF). Method: This study was conducted at the Military Cardiac Centre in Sana'a, Yemen, offering diagnostics, therapeutics, and surgical services to the Yemeni population. It was a 1:2 unmatched case-control study conducted from April 1 to September 30, 2025, involving a total of 180 participants (60 cases with an ejection fraction < 55% and 120 controls with an ejection fraction > 55%). Participants provided verbal consent and underwent clinical examinations, including electrocardiography. Results: The study compares ejection fraction (EF) results across different measurement methods, showing mean EF values of 42.25 (M mod), 37.41 (Simpson), and 38.33 (eyeballing), with a significant p-value (<0.001) between cases and controls. In systolic left ventricle (LV) parameters, case means for S med (6.6) and S lat (7.26), along with MAPSE M (9.41) and MAPSE I (11.44), were recorded with a significant p-value (<0.001). Correlations were noted for S med (0.62) and S lat (0.60), with odds ratios (26.17–17.70) and confidence intervals (CI=3.59–2.99). Conclusions: This study finds a strong positive correlation between TDI-derived S′ velocity and left ventricular ejection fraction (LVEF), identifying S′ as a reliable marker of systolic function. It also supports MAPSE as an effective and clinically relevant marker, especially in low-resource settings.                 Peer Review History: Received 5 April 2026;   Reviewed 8 May 2026; Accepted  10 June; Available online 15 July 2026 Academic Editor: Dr. Ahmad Najib, Universitas Muslim Indonesia,  Indonesia, ahmad.najib@umi.ac.id Reviewers: Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, sansan4240732@163.com Dr. Gülay B Anadolu, Anadolu University, Eskisehir, Turkey, gbuyukko@anadolu.edu.tr 07 15 2026 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v11i3.1569 https://ujpronline.com/index.php/journal/article/view/1569 https://ujpronline.com/index.php/journal/article/download/1569/2173 https://ujpronline.com/index.php/journal/article/download/1569/2173 https://ujpronline.com/index.php/journal/article/download/1569/2174 https://ujpronline.com/index.php/journal/article/download/1569/2204