_1778830356 20260515073236000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 05 15 2026 Emmanuel Ifeanyi Obeagu Angela Amarachi Obeagu HIV continues to impose a disproportionate burden on children in resource-limited settings, where socioeconomic constraints, fragile health systems, and limited access to prevention services impede progress toward global elimination goals. Community-based HIV prevention models have emerged as critical approaches to address structural and behavioral vulnerabilities, reduce pediatric HIV incidence, and strengthen linkages to care. This narrative review synthesizes current evidence on community-led, family-centered, and health system–supported interventions that have demonstrated effectiveness in preventing HIV acquisition among children. Key approaches include early maternal HIV diagnosis, prevention of mother-to-child transmission (PMTCT), community health worker (CHW) programs, school- and faith-based initiatives, social protection strategies, and innovations in community testing and digital health. Although notable progress has been made, gaps persist in coverage, sustainability, multi sector collaboration, and adaptation to humanitarian settings. Strengthening community ownership, leveraging local capacity, and integrating child-focused HIV prevention with broader social welfare programs are essential to achieving equitable outcomes.                 Peer Review History: Received 4 February 2026;   Reviewed 17 March 2026; Accepted  11 April; Available online 15 May 2026 Academic Editor: Dr. Muhammad Zahid Iqbal, AIMST University, Malaysia, drmmziqbal@gmail.com Reviewers: Dr. Mohammad Tauseef, Department of Pharmaceutical Sciences, College of Pharmacy, Chicago State University, mtauseef@csu.edu Dr. Mahmoud S. Abdallah, University of Sadat city, Egypt, dr_samy777@yahoo.com 05 15 2026 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v11i2.1542 https://ujpronline.com/index.php/journal/article/view/1542 https://ujpronline.com/index.php/journal/article/download/1542/2142 https://ujpronline.com/index.php/journal/article/download/1542/2142 https://ujpronline.com/index.php/journal/article/download/1542/2143 https://ujpronline.com/index.php/journal/article/download/1542/2160