_1778830184 20260515072944000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 05 15 2026 Chioma Adaeze Duru Obinna Ajah Ikenna Elvis Nnaoma Rich C Joseph Background: Benign Prostatic Hyperplasia (BPH) is an age-related condition characterized by prostate enlargement, lower urinary tract symptoms (LUTS), and persistent inflammation. Although conventional treatments such as α1-adrenergic blockers and 5α-reductase inhibitors (e.g., finasteride) can relieve symptoms, their use is frequently associated with undesirable side effects. This study evaluated the effect of ethanol extract of Eleusine coracana leaves on serum lipid profile and inflammatory cytokines in a testosterone propionate (TP)-induced BPH rat model. Methods: Thirty male Wistar rats were randomly assigned to six groups: normal control, TP-induced BPH control, finasteride-treated group, and three groups treated with E. coracana extract at doses of 100, 200, and 400 mg/kg. Serum lipid parameters (triglycerides, total cholesterol, HDL, and LDL) and inflammatory cytokines (IL-6 and TNF-α) were assessed, together with prostatic levels of IL-6 and TNF-α. Results: The results revealed that TP-induced BPH caused significant dyslipidemia (increased TG, TC, LDL, and decreased HDL) and elevated systemic and prostatic cytokines compared to controls. Treatment with E. coracana extract significantly improved lipid profiles and reduced pro-inflammatory cytokine levels in a dose-dependent manner, with effects comparable to finasteride. Notably, the 400 mg/kg extract normalized HDL and prostatic IL-6 levels, indicating strong anti-inflammatory and lipid-modulating activity. Conclusion: These findings suggest that E. coracana leaf extract may serve as a promising adjunct or alternative therapy for BPH, particularly in patients with concurrent metabolic risk factors.                   Peer Review History: Received 6 February 2026;   Reviewed 12 March 2026; Accepted  15 April; Available online 15 May 2026 Academic Editor: Dr. Jennifer Audu-Peter, University of Jos, Nigeria, drambia44@gmail.com Reviewers: Dr. Alfonso Alexander Aguileral, University of Veracruz,  Mexico, aalexander_2000@yahoo.com Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my 05 15 2026 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v11i2.1535 https://ujpronline.com/index.php/journal/article/view/1535 https://ujpronline.com/index.php/journal/article/download/1535/2132 https://ujpronline.com/index.php/journal/article/download/1535/2132 https://ujpronline.com/index.php/journal/article/download/1535/2133 https://ujpronline.com/index.php/journal/article/download/1535/2155